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Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis
The reported proconvulsive actions of Enk are supposed to depend on the activation of DOPr. The threshold for pentylenetetrazole (PTZ)-induced seizures was not altered by pretreatment with the specific DOPr agonist SNC80 (2 mg/kg; 30 min before PTZ) in WT mice. By contrast, pretreatment with the specific DOPr antagonist naltrindole (1 mg/kg; 30 min before PTZ) increased seizure threshold by about 25% (Figure 1A), this confirms DOPr mediated proconvulsant effects and suggests that exogenous agonists cannot further enhance the effects of endogenous Enk in WT mice.Scorrano Erotic Massage
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